Publications 2006

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List of publications 2006 from the Consortium.
Links to full articles when available. Some journals require subscription.

[ View abstracts of some of the articles>> ]

Abadi, A.H., Abou-Seri, S.M., Abdel-Rahman, D.E., Klein, C., Lozach, O. and Meijer, L.

Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents.

Eur. J. Med. Chem. 2006, 41, 296-305.>>
Alakurtti, S., Mäkelä,T., Koskimies, S. and Yli-Kauhaluoma, J.

Pharmacological properties of the ubiquitous natural product betulin

European Journal of Pharmaceutical Sciences 2006, 29, 1, 1-13.>>
Aloisi A., DI Gregorio S., Stagno F., Guglielmo P., Mannino F., Sormani M.P., Bruzzi P., Gambacorti-Passerini C., Saglio G., Venuta S., Giustolisi R., Messina A., Vigneri P.G.

BCR-ABL nuclear entrapment kills human CML cells: ex vivo study on 35 patients with the combination of Imatinib Mesylate and Leptomycin B.

Blood, 2006, 107, 1591-98. >>
Arrigoni G., Resjo S., Levander F., Nilsson R., Degerman E., Quadroni M., Pinna L. A., and James P. (2006)

Chemical derivatization of phosphoserine and phosphothreonine containing peptides to increase sensitivity for MALDI-based analysis and for selectivity of MS/MS analysis

 Proteomics 6, 757-766.
Assouline S., Laneuville P., Gambacorti-Passerini C.

Panniculitis during Dasatinib Therapy for Imatinib-Resistant Chronic Myelogenous Leukemia.

New Engl. J of Med, 2006, 354, 2623-2625.>>
Barluenga, S., Dakas, P.Y., Ferandin, Y., Meijer, L. and Winssinger, N.

Modular asymmetric synthesis of Aigialomycin D, a kinase-inhibitory scaffold.

Angew. Chem. Ind. Ed. Engl. 2006, 45, 3951-354. >>
Bustos V. H., Ferrarese A., Venerando A., Marin O., Allende J. E., and Pinna L. A. (2006)

The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1.

Proc. Natl. Acad. Sci. U S A. 103, 19725-19730.
Coluccia A.M.L., Benati D., Dekhil H., Lan C., Marchesi E., Gambacorti-Passerini C.

Inhibition of Src-mediated beta-Catenin tyrosine phosphorylation in Colorectal cancer cells leads to decreased transcriptional activity and induces a proliferation block.

Cancer Res., 2006, 66, 2279-86. >>
Cozza G., Bonvini P., Zorzi E., Poletto G., Pagano M. A., Sarno S., Donella-Deana A., Zagotto G., Rosolen A., Pinna L. A., Meggio F., and Moro S. (2006)

Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.

J Med. Chem. 49, 2363-2366.

Gambacorti-Passerini C.

Prognostic variables in patients with chronic myeloid leukemia treated with imatinib.

Haematologica. 2006, 91, 145. >>
Kunick C., Bleeker C. Pruehs C., Totzke F., Schaechtele C., Kubbutat M. H. G. and Link A.

Matrix COMPARE analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydro-benzo[b]cylopenta[e] azepine-4,10(1H,5H)-diones.

Bioorg. Med. Chem. Lett. 2006, 16, 2148-2153. >>
Kunick, C., Lemcke, T., Meijer, L.:


In: Inhibitors of cyclin-dependent kinases as antitumor agents, P. J. Smith, E. Yue (Editors), CRC Press LLC, Boca Raton (USA), 2006, 227-249.
Meijer, L., Guyard, N., Skaltsounis, L.A. and Eisenbrand, G. (Editors) 2006.

 “Indirubin, the red shade of indigo”. Editions
« Life in Progress », Station Biologique, Roscoff, (27 chapters), 297 pp.
Pagano M. A., Cesaro L., Meggio F., Pinna L. A. (2006)

Protein kinase CK2: a newcomer in the 'druggable kinome'.

Biochem. Soc. Trans. 34, 1303-1306.

[ PDF ]
Ribas, J., Boix, J. and Meijer, L.

(R)-Roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastoma cells to Nutlin-3 induced apoptosis.

Exp. Cell Res. 2006, 312, 12, 2394-2400.>>
Ribas, J., Bettayeb, K., Ferandin, Y., Knockaert, M., Totzke, F., Schächtele, C., Mester, J., Polychronopoulos, P., Magiatis, P., Skaltsounis, A.L., Boix, J. and Meijer, L.

7-bromoindirubin-3’-oxime induces caspase-independent cell death.

Oncogene, 2006. >>
Routier, S., Mérour, J.Y., Dias, N., Lansiaux, A., Bailly, C., Lozach, O. and Meijer, L..

Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.

J. Med. Chem. 2006, 49, 789-799.

Abstract >>
Full article available at:
Ruzza P., Cesaro L., Tourwe D., Calderan A., Biondi B., Maes V., Menegazzo I., Osler A., Rubini C., Guiotto A., Pinna L. A., Borin G., and Donella-Deana A. (2006)

Spatial conformation and topography of the tyrosine aromatic ring in substrate recognition by protein tyrosine kinases

J Med. Chem. 49, 1916-1924.
Ruzza P., Siligardi G., Donella-Deana A., Calderan A., Hussain R., Rubini C., Cesaro L., Osler A., Guiotto A., Pinna L. A., and Borin G. (2006)

4-Fluoroproline derivative peptides: effect on PPII conformation and SH3 affinity

J. Pept. Sci. 12, 462-471.>>
Salvi M., Sarno S., Marin O., Meggio F., Itarte E. and Pinna L. A. (2006)

Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits

FEBS Lett. 580, 3948-3952.>>
Testard, A., Logé, C., Léger, B., Robert, J.M., Lozach, O., Blairvacq, M., Meijer, L., Thiéry, V. and Besson, T.

Thiazolo[5,4-f]quinazolin-9-one derivatives, inhibitors of glycogen synthase kinase-3ß.

Bioorg. Med. Chem. Lett. 2006, 16, 3419-3423.>>
Tibaldi E., Arrigoni G., Brunati A. M., James P., and Pinna L. A. (2006)

Analysis of a sub-proteome which co-purifies with and is phosphorylated by the Golgi casein kinase

Cell Mol. Life Sci. 63, 378-389.>>
Trapp, J., Jochum, A., Meier, R., Saunders, L., Marshall, B., Kunick, C., Verdin, E., Goekjian, P., Sippl, W., Jung, M.:

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases - from kinase to sirtuin inhibition

J. Med. Chem. 2006, 49, 7307-7316.

ACS Publications >>
Vandromme, L., Piguel, S., Lozach, O., Meijer, L., Legraverend, M., and Grierson, D.S.

Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as CDK inhibitors.

Bioorg. Med. Chem. Lett. 2006, 16, 3144-3146.>>