Publications 2005

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List of publications 2005 from the Consortium.
Links to full articles when available. Some journals require subscription.

[ View abstracts of some of the articles>> ]

Bach, S., Knockaert, M., Lozach, O., Reinhardt, J., Baratte, B., Schmitt, S., Coburn, S.P., Tang, L., Jiang. T., Liang, D.C., Galons, H., Dierick, J.F., Totzke, F., Schächtele, C., Lerman, A.S., Carnero, A., Wan, Y., Gray, N. and Meijer, L.

Roscovitine targets: protein kinases and pyridoxal kinase.

J. Biol. Chem. 2005, 280, 31208-31219.

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Bagossi, P., Horváth, G., Vereb, G., Jr., Szöllősi, J. & Tőzser, J.

Molecular Modeling of Nearly Full-Length ErbB2 Receptor. 

Biophys J. 2005, 88, 1354-1363.

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Battistutta R., Mazzorana M., Sarno S., Kazimierczuk Z., Zanotti G. and Pinna L. A. (2005)
Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole

Chemistry & Biol. 12, 1211-1219 >>

Belmont, P., Belhadj, T.
 An Efficient and Simple Aminobenzannulation Reaction: Pyrrolidine as a Trigger for the Synthesis of 1-Amino-Acridines.
 Org. Lett. 2005, 7, 1793-1795.

 Article available for subscription at:
Braña, M.F., Cacho, M., García, M.L., Mayoral, E.P., López, B., de Pascual-Teresa, B., Ramos, A., Acero, N., Llinares, F., Muñoz-Mingarro, D., Lozach, O. and Meijer, L.

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.

J. Med. Chem. 2005, 48, 6843-6854.

Pdf and supplementary material available at

Bustos V. H. , Marin C., Meggio F., Cesaro L., Allende C. C. , Allende J. E., and Pinna L. A. (2005)

Generation of protein kinase Ck1 alpha mutants which discriminate between canonical and non-canonical substrates

Biochem. J. 391, 417-424.
Coluccia, A. M., Gunby, R. H., Tartari, C. J., Scapozza, L., Gambacorti-Passerini, C., and Passoni, L.

lymphoma kinase and its signalling molecules as novel targets in lymphoma therapy.

Expert Opin Ther Targets, 2005, 9: 515-532.

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Coluccia A.M.L., Benati D., Dekhil H., Lan C., Marchesi E., Gambacorti-Passerini C.

Inhibition of Src-mediated beta-Catenin tyrosine phosphorylation in Colorectal cancer cells leads to decreased transcriptional activity and induces a proliferation block.

Cancer Res., 2006, 66, 2279-86.
Donella-Deana A., Marin O., Cesaro L., Gunby R.H., Ferrarese A., Tartari C., Mologni L., Scapozza L., Gambacorti-Passerini C., Pinna L.

Unique substrate specificity of Anaplastic Lymphoma Kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity

Biochemistry, 2005, 44(23):8533-42.

 Abstract >>
Ferrari S., Marin O., Pagano M. A., Meggio F., Hess D., El-Shemerly M., Krystyniak A., and Pinna L. A. (2005)

Aurora-A site specificity: a study with synthetic peptide substrates

Biochem. J. 390, 293-302.

Full article>>
Gambacorti-Passerini C.

Gene expression analysis fails to identify patients with chronic myeloid leukemia who will achieve cytogenetic response to imatinib.

Haematologica 2005;90:434. >>

Gambacorti-Passerini C., Gasser M., Hafedh S., Scapozza L.

BMS-354825 binding mode in Ableson kinase revealed by molecular docking studies.

Leukemia, 2005, 19, 1267−1269.

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  Gunby, R. H., Tartari, C. J., Porchia, F., Donella-Deana, A., Scapozza, L., and Gambacorti-Passerini, C.

 An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase.

Haematologica, 2005, 90: 988-990.

Abstract >>
Pdf (112 KB) available for downloading at: >>

 Haider U.G., Roos T.U., Kontaridis M.I., Neel B.G., Sorescu D., Griendling K.K., Vollmar A.M., Dirsch V.M.

Resveratrol inhibits angiotensin II- and EGF-mediated Akt activation - role of Gab1 and Shp2.

Mol Pharmacol. 2005 Apr 22;

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 Horváth, G., Petrás, M., Szentesi, G., Fábián, Á., Park, J. W., Vereb, G., Jr. & Szöllősi, J.

Selecting the right fluorophores and flow cytometer for fluorescence resonance energy transfer measurements.
Cytometry A 2005, 62(2): 148-57

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Kunick C., Zeng Z., Gussio R., Zaharevitz D., Leost M., Totzke F., Schächtele C., Kubbutat M. H. G., Meijer L., Lemcke T.

Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

ChemBioChem, 2005, 6, 3, 541-549.

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Di Maira G., Salvi M., Arrigoni G., Marin O., Sarno S., Brustolon F., Pinna L. A., and Ruzzene M. (2005)

Protein kinase CK2 phosphorylates and upregulates Akt/PKB

Cell Death Diff. 12, 668-677. >>
Mocanu, M., Fazekas, Z., Petrás, M., Nagy, P., Sebestyén, Z., Isola, J., Tímár, J., Park, J. W., Vereb, G., Jr. & Szöllősi, J.

Associations of ErbB2, ß1-integrin and lipid rafts on Herceptin® (Trastuzumab) resistant and sensitive tumor cell lines.

Cancer Letters. 2005, 227(2):201-212.

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Full article available at:

Mologni L., Sala E., Riva B., Cesaro L., Cazzaniga S., Redaelli S., Marin O., Pasquato N., Donella-Deana A., Gambacorti-Passerini C.

Expression, purification and inhibition of human RET tyrosine kinase

Protein Expression & Purification, 2005, 41, 1, 177-185.

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Nagy, P., Bene, L., Hyun, W. C., Vereb, G., Jr., Braun, M., Antz, C., Paysan, J.,., Damjanovich, S. Park, J. W & Szöllősi, J.

Novel calibration method for flow cytometric determination of fluorescence resonance energy transfer efficiency between visible fluorescent proteins.

Cytometry A. 2005, 67(2): 86-96.

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Full article available at:

Pagano M. A., Sarno S., Poletto G., Cozza G., Pinna L. A., and Meggio F. (2005)

 Autophosphorylation at the regulatory beta subunit reflects the supramolecular organization of protein kinase CK2.

 Mol. Cell. Biochem. 274, 23-29.
Patin, A., Belmont, P.

A New Route to Acridines: Pauson-Khand Reaction on Quinoline-Bearing 1-En-7-ynes Leading to Novel Tetrahydrocyclopenta[c]acridine-2,5-diones.

Synthesis 2005, 2400-2406.

Abstract >>>>
Perseghin P,, Gambacorti-Passerini C., Tornaghi L., Dassi M., Pioltelli P., Parma M., Colnaghi F., Giudici G., Elli E., Fumagalli M., Ponchio L., Biondi A., Pogliani E.

Peripheral blood stem cell collection in CML patients after treatment with imatinib mesylate and complete cytogenetic response.

Transfusion 2005, 45, 1214-20.

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Piazza R., Magistroni V., Gasser M., Andreoni F., Galietta A., Scapozza L., Gambacorti-Passerini C.

Evidence for D276G and L364I Bcr-Abl mutations in Ph+ leukemic cells obtained from patients resistant to Imatinib.

Leukemia 2005, 19, 132-134.

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[ Full article ] (Pdf, 161 KB)
 Piazza R., Magistroni V., Andreoni F., Franceschino A., Tornaghi L., Varella-Garcia M., Bungaro S., Colnaghi F., Corneo G., Pogliani E.M., Gambacorti-Passerini C.

Imatinib dose increase up to 1200 mg daily can induce durable complete cytogenetic remissions (CCR) in relapsed Ph+ chronic myeloid leukemia (CML) patients.

Leukemia, 2005, 19, 1985–1987. >>

Piazza R.G., Magistroni V., Franceschino A., Gambacorti-Passerini C.

 ‘D276G mutation is associated with a poor prognosis in imatinib mesylate-resistant chronic myeloid leukemia patients'. Response to Leguay et al.

Leukemia 19, 2005, 2333-2334. >>
 Sarno S., Salvi M., Battistutta R., Zanotti G., and Pinna L. A. (2005)

Features and potentials of ATP-site directed CK2 inhibitors

Biochim. Biophys. Acta – Proteins and Proteomics 1754, 263-270. >>

Sarno S., Ruzzene M., Frascella P., Pagano M. A., Meggio F., Zambon A., Mazzorana M., Di Maira G., Lucchini V., and Pinna L. A. (2005)

 Development and exploitation of CK2 inhibitors

Mol. Cell. Biochem. 274, 69-76.>>
Tang, L., Li, M.H., Cao, P., Wang, F., Chang, W.R., Bach, S., Reinhardt, J., Koken, M., Galons, H., Wan, Y., Gray, N., Meijer, L., Jiang. T. and Liang, D.C.

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.

J. Biol. Chem. 2005, 280, 31220-31229.

 Abstract >>
Wu, Z.L., Aryal, P., Lozach, O., Meijer, L. and Guengerich, F.P..

Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6.

Chem. & Biodiv. 2005, 2, 51-65.

Pdf available at
Xie X, Lemcke T, Gussio R, Zaharevitz D W, Leost M, Meijer L, Kunick C.

Epoxide-containing side chains enhance antiproliferative activity of paullones.

Eur. J. Med. Chem. 2005, 40, 655-661.

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