Here's a list of publications from our Consortium.
Links to full articles when available. Some journals require subscription.

Dosis Theme Issue "Protein Kinase Research" provides a closer look to protein kinases, especially those studied by our Consortium. The issue was published in Helsinki Drug Research (HDR2006) Congress in July 2006.

[ 2007 ]       [ 2006 ]        [ 2005 ]      [ 2004 ]

Latest publications

Arrigoni G., Pagano M. A., Sarno S., Cesaro L., James P., Pinna L. A. (2008)

Mass spectrometry analysis of a protein kinase CK2beta subunit interactome isolated from mouse brain by affinity chromatography.

J. Proteome Res. 7, 990-1000.>>
Barok M., Balázs M., Nagy P., Rákosy Z., Treszl A., Tóth E., Juhász I., Park J. W., Isola J., Vereb G., Szöllõsi J. (2008).

Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumor.

Cancer Lett 260(1-2):198-208
Bekker O. B., Elizarov S. M., Alekseeva M. G., Lubimova I. K., Danilenko V. N. (2008)

 The Ca2+-dependent modulation of the antibiotics resistance in Streptomyces lividans 66 and Streptomyces coelicolor А3(2) //

Microbiology 2008. In press.
Bouchikhi F., Rossignol E., Sancelme M., Aboab B., Anizon F., Fabbro D., Prudhomme M., Moreau P. (2008)

Synthesis and biological evaluation of diversely substituted indolin-2-ones.

Eur. J. Med. Chem, in press.>>

Bourdon B., Corbet M., Fontaine P., Goekjian P. G., Gueyrard D. (2008)

Synthesis of enol ethers from lactones using Julia modified olefination reagents: application to the preparation of tri- and tetrasubstituted exoglycals.

Tetrahedron Letters 49(5), 747-749>>

Chilin A., Battistutta R., Bortolato A., Cozza G., Zanatta S., Poletto G., Mazzorana M., Zagotto G., Uriarte E., Guiotto A., Pinna L. A., Meggio F., Moro S.. (2008)

Coumarin as Attractive Casein Kinase 2 (CK2) Inhibitor Scaffold: An Integrate Approach To Elucidate the Putative Binding Motif and Explain Structure-Activity Relationships.

J Med Chem. 2008 Feb 28;51(4):752-9>>

Corbet M., Bourdon B., Gueyrard D., Goekjian P. G. (2008)

A Julia olefination approach to the synthesis of functionalized enol ethers and their transformation into carbohydrate-derived spiroketals.

Tetrahedron Letters 49(5), 750-754.>>
Echalier A., Bettayeb K., Ferandin Y., Lozach O., Clement M., Valette A., Liger F., Marquet B., Morris J. C., Endicott J. A., Joseph B., Meijer L. (2008)

Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex.

J Med Chem 51: 737-751>>
Eiring A. M., Neviani P., Santhanam R., Oaks J. J., Chang J. S., Notari M., Willis W., Gambacorti-Passerini C., Volinia S., Marcucci G., Caligiuri M. A., Leone G. W., Perrotti D. (2008)
Identification of novel post-transcriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis.

Blood 111(2):816-28.>>
Fewer, D.P., Tooming-Klunderud A., Jokela J., Wahlsten M., Rouhiainen L., Kristensen T., Rohrlack T., Jakobsen K. and Sivonen K. (2008)

Natural occurrence of microcystin synthetase deletion mutants capable of producing microcystins in strains of genus Anabaena (cyanobacterium).

Microbiology 154: 1007-1014.

Galkin, A., Pakkanen, J., Vuorela, P. (2008)

Development of automated 7-day 96-well Caco-2 cell culture model.

Pharmazie. 2008 Jun;63 (6):464-9

Halinen, K., Fewer D. P., Sihvonen L. M., Lyra C, Eronen E. and Sivonen K. (2008).

Genetic diversity in strains of the genus Anabaena isolated from planktonic and benthic habitats of the Gulf of Finland (Baltic Sea).

FEMS Microbiology Ecology (in press)
Hampson P., Kavanagh D., Smith E., Wang K., Lord J. M. and Rainger G. E. (2008)

The anti-tumor agent, Ingenol-3-Angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-δ dependent manner.

Cancer Immunol Immunother 57 (8):1241-1251.>>
Hiebel M-A, Pelotier B., Goekjian P., Piva O. (2008).

2,6-Disubstituted Tetrahydropyrans by Tandem Cross-Metathesis-Iodocyclisation.

Eur. J. Org. Chem. 713–720.>>
Hiebel M-A, Pelotier B., Lhoste P., Piva O. (2008)

Synthesis of Bistramide A and analogues Part.1: Stereo-selective access to nor-methyl tetrahydropyran subunit.

Synlett (accepted March 2008)
Jacquemard, U., Routier, S., Dias, N., Lansiaux, A., Bailly, C., Logé, C., Robert, J.M., Lozach, O., Meijer, L. ,Mérour, J.Y. (2008).

Synthesis of 3,5- bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and DNA binders.

Bioorg. Med. Chem., in press
Logé, C., Testard, A., Thiéry, V., Lozach, O., Blairvacq, M., Robert, J.M., Meijer, L. , Besson, T., (2008).

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1) / glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.

Eur. J. Med. Chem. 43 (7), 1469-1477>>
McCracken, S.R.C., Heer, R., Mathers, M.E., Jenkins, B.L., Edwards, J., Robson, C.N., Marquez, R., Cohen, P. Leung, H.Y. (2008)

Clinical significance of abnormal extracellular signal-regulated kinase 5 (ERK5) expression in human prostate cancer.

Oncogene 27, 2978-2988>>
Mendoza, H., Campbell, D.G., Burness, K., Hastie, J. and Cohen, P. (2008).

Identification of novel phosphorylation sites in the TAK1 complex.

Biochem. J. 409, 711-722
Merckx A., Echalier A., Langford K., Sicard A., Langsley G., Joore J., Doerig C., Noble M., Endicott J. (2008)

Structures of P. falciparum Protein Kinase 7 Identify an Activation Motif and Leads for Inhibitor Design.

Structure 16: 228-238>>
Morton S., Hesson L., Peggie M. Cohen P. (2008).

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.

FEBS Lett 582, 997-1002.>>
Tartari C. J., Gunby R. H., Coluccia A. M., Sottocornola R., Cimbro B., Scapozza L., Donella-Deana A., Pinna L. A., and Gambacorti-Passerini C. (2008)

Characterization of some molecular mechanisms governing autoactivation of the catalytic domain of the anaplastic lymphoma kinase.

J. Biol. Chem. 283, 3743-3750.

Wakata A., Cahill S. M., Blumenstein M., Gunby R. H., Jockusch S., Marti A. A., Cimbro B., Gambacorti-Passerini C., Donella-Deana A., Pinna L. A., Turro N. J., and Lawrence D. S. (2008)

 A mechanistic design principle for protein tyrosine kinase sensors: application to a validated cancer target.

Org. Lett. 10, 301-304.>>